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, pH, oxygen levels) within the BM niche ( 2.3.2 CD38 and extracellular NAD + metabolism Nucleotides have a second life as intercellular communicators and signal transducers in the BM niche ( NAD + metabolism is governed by cell surface ectoenzymes, which work together to disassemble extracellular and intracellular nucleotides extruded from cells via active channeling mechanisms or by microvesicles (MVs)